Health Impacts of Phthalates, Polystyrene, and Other Chemicals Used to Make Plastic

 

Baby with bottleIn addition to its effect on soil, water, animals and the oceans, plastic--or rather the chemicals used to make plastic--has been shown to have a direct, negative impact on human health. In recent years, phthalates and polystyrene have consistently made headlines as various studies have emerged solidifying the link between these chemicals, common in many plastics, and various health problems, including cancer, diabetes, obesity and ADD. 

Many thanks to Breast Cancer Fund for providing much of the information here on pthalates.

Pthalates

Phthalates are a group of endocrine-disrupting chemicals commonly used to render plastics soft and flexible. They are found in a wide variety of common products including plastics (e.g., children’s toys), cosmetics, pharmaceuticals, baby care products, building materials, modeling clay, automobiles, cleaning materials and insecticides. Phthalates are readily absorbed through the skin and can also enter the body through ingestion, inhalation or medical injection procedures.

Phthalates have been found in indoor air and dust and in human urine and blood samples. National data collected by the CDC show that levels are highest in children ages 6 to 11 and in women, and that blacks have higher levels of phthalates than do whites (CDC, 2005). Phthalates have also been detected in human breast milk and urine. Phthalates cross the human placenta, exposing fetuses to the hazards associated with exposure to an important class of EDCs during this critical period of development. Young infants are also exposed to high levels of phthalates, with measurable levels of seven different phthalates being found in infants born between 2000 and 2005.

Phthalates are considered to be endocrine disruptors because of their complex effects on several hormonal systems including the estrogen and androgen hormone systems. Some phthalates, including butyl benzyl phthalate (BBP) and di-n-butyl phthalate (DBP), act as weak estrogens in cell culture systems. They can bind to estrogen receptors (ER), induce estrogen-appropriate cellular responses and act additively with estradiol in altering these systems. Phthalates also bind weakly to the androgen receptor (AR), disrupting the cellular actions ordinarily initiated by the androgens (Borch, 2006). Those that bind most strongly to the AR, and therefore might be expected to exert the greatest effects through this pathway, include DBP, di-i-butyl phthalate (DiBP) and butyl benzyl phthalate (BBP).

The endocrine-disrupting properties of this class of chemicals have been well established in the offspring of mother rats who had been treated with phthalates while pregnant. Phthalates have been shown to disrupt the development and functioning of male and female reproductive systems by interfering with the production of testosterone and estradiol, respectively. Abnormalities in male offspring exposed prenatally included nipple retention, shortened ano-genital distance and increased cryptorchidism (undescended testes). Exposure of human mothers to phthalates, as measured by analysis of their urine samples, has also been associated with shortened ano-genital distances in their newborn sons—a measure of feminization of external genitalia.

A recent case-control study examined phthalate levels in apparently healthy girls who went through thelarche (breast development) before the age of 8, as compared with girls who underwent precocious puberty because of abnormalities in their neuroendocrine systems and with girls who were progressing through puberty at normal ages. Increased levels of monomethyl phthalate (MMP) were associated with early thelarche group, but not either of the comparison groups. Early breast development in otherwise healthy girls is associated with an increased risk for breast cancer.

Polystyrene

Polystyrene is a composite material made out of the monomer styrene. It is a versatile material and can be molded into a number of different consumer products, but is normally used for food service wear. Popular uses for polystyrene include plates, cups, bowls, and to-go food containers. As a material, styrene is a known carcinogen in lab animals, and has a high liklihood for producing the same effects in humans. Currently, the FDA permits styrene to be used as a direct food additive, and it readily migrates from food packaging into the food itself.

The US EPA reports that 100% of humans have styrene in their bodies, originating from contact through food containers, inhaling indoor smoke, or drinking contaminated water. Everyday exposure can range from 1 µg/person/day to >100 µg/person/day, but occupational exposure can be much greater, occurring in polystyrene factories, the reinforced plastics industry, and in boat making.

The carcinogenic effects of styrene include elevated rates of lymphoma, hematopoiesis, and leukemia in reinforced plastics workers, primarily through inhalation. Exposure to styrene can also cause mucous membrane irritation, eye irritation, gastrointestinal effects, listlessness, impairment of balance, and central nervous system disorders such as depression, headache, fatigue, and muscle weakness among many others. In animal studies, styrene has been found to cause hearing loss, changes to the lining of the nose, and liver damage. In vitro studies in mammals have found mutagenic effects in cell cultures, which could mean complications with pregnancy and birthing later on.

 

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Studies and reports

Adams, W., Xu, Y., et al. (2011). “Predicting the migration rate of dialkyl organotins from PVC pipe into water.Environmental Science & Technology: 1-20.

Andrea, S., et al. (2012). “Co-leaching of brominated compounds and antimony from bottled water.” Environment International 38. 1: 45-53.

Berman, T., et al. (2009). “Phthalate exposure among pregnant women in Jerusalem, Israel: Results of a pilot study.” Environment International 35. 2: 353-357.

Betts, K. (2011). “Children’s Exposure to PBDEs Binational Comparison Highlights Dramatic Differences.Environmental Health Perspectives 119. 10: A442.

Casas, L., et al. (2011). “Urinary concentrations of phthalates and phenols in a population of Spanish pregnant women and children.” Environment International 37.5: 858-866.

Centers for Disease Control and Prevention (2009). Fourth National Report on Human Exposure to Environmental Chemicals. D. o. H. a. H. Services. Washington DC.

Dey, S., Soliman, A., Merajver, S. (2009). “Xenoestrogens may be the cause of high and increasing rates of hormone receptor positive breast cancer in the world.” Medical Hypotheses 72. 6: 652-656.

Diamanti-Kandarakis, E., Bourguignon, J., Giudice, L.C., Haser, R., Prins, G.S, Soto, A.M,. Zoeller, T., Gore, A.C. (2009). "Endocrine-Disrupting Chemicals: An Endocrine Society Scientific Statement." Endocrine Reviews. 30(4), 293-342.

Guo, Y., Alomirah, H., Cho, H., Minh, T., Mohd, M., Nakata, H., Kannan, K. (2011). “Occurrence of Phthalate Metabolites in Human Urine from Several Asian Countries.Environmental Science & Technology 45: 3138-3144.

Houlihan, J., Wiles, R. (2000). “Does a common chemical in nail polish pose risks to human health?” Environmental Working Group.

Koch, H. M. and A. M. Calafat (2009). "Human body burdens of chemicals used in plastic manufacture." Philosophical Transactions of the Royal Society B: Biological Sciences 364.1526: 2063-2078.

Lin, S., et al. (2011). “Phthalate exposure in pregnant women and their children in central Taiwan.” Chemosphere 82. 7: 947-955.

Maxwell, T., Milne, G., Fales, H., Law, N. (1973). “Plasticizers in Blood-Real or Artifactual?Environmental Health Perspectives: 139-140.

Meeker, J. D., S. Sathyanarayana, et al. (2009). "Phthalates and other additives in plastics: human exposure and associated health outcomes." Philosophical Transactions of the Royal Society B: Biological Sciences 364.1526: 2097-2113.

Meyers, P. and W. Hessler. (2007). "Does 'the dose make the poison?': Extensive results challenge a core assumption in toxicology." Environmental Health News.

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Rider, C. V., J. Furr, et al. (2008). "A mixture of seven antiandrogens induces reproductive malformations in rats." International Journal of Andrology 31.2: 249–262.

Rubin, R., Jaeger, R. (1973). “Some Pharmacologic and Toxicologic Effects of Di 2-ethylhexyl Phthalate (DEHP) and Other Plasticizers.Environmental Health Perspectives: 53-59.

Shanmuganathan, D., Megharaj, M., Chen, Z., Naidu, R. (2011). “Polybrominated diphenyl ethers (PBDEs) in marine foodstuffs in Australia: Residue levels and contamination status of PBDEs.Marine Pollution Bulletin 63. 5-12: 154-159.

Shaxson, L. (2009). "Structuring policy problems for plastics, the environment and human health: reflections from the UK." Philosophical Transactions of the Royal Society B: Biological Sciences 364.1526: 2141-2151.

Swan, S. (2008). "Environmental Phthalate Exposure in Relation to Reproductive Outcomes and Other Health Endpoints in Humans." Environ Res. 108(2): 177-184.

Talsness, C. E., A. J. M. Andrade, et al. (2009). "Components of plastic: experimental studies in animals and relevance for human health." Philosophical Transactions of the Royal Society B: Biological Sciences 364.1526: 2079-2096.

Thompson, R. C., C. J. Moore, et al. (2009). "Plastics, the environment and human health: current consensus and future trends." Philosophical Transactions of the Royal Society B: Biological Sciences 364.1526: 2153-2166.

Thornton, J. W., M. McCally, et al. "Biomonitoring of Industrial Pollutants: Health and Policy Implications of the Chemical Body Burden." Public Health Reports 117.315.

Vandenberg, L., et al. "Hormones and Endocrine Disrupting Chemicals: Low-Dose Effects and Nonmonotonic Dose Responses." Endocrine Reviews 2011-1050.

Wiberg, G.S. (1976). “Consumer Hazards of Plastics.Environmental Health Perspectives 17: 221-225.

Wiseman, S., Wan, Y., Chang, H., Zhang, X., Hecker, M., Jones, P., Giesy, J. (2011). “Polybrominated diphenyl ethers and their hydroxylated/methoxylated analogs: Environmental sources, metabolic relationships, and relative toxicities.Marine Pollution Bulletin 63. 5-12: 179-188.

Yang, C., et al. (2011). “Most Plastic Products Release Estrogenic Chemicals: A Potential Health Problem That Can Be Solved.” Environmental Health Perspectives 119. 7: 989-997.

Ye, L., Zhao, B., Hu, G., Chu, Y., Ge, R. (2011). “Inhibition of human and rat testicular steroidogenic enzyme activities by bisphenol A.” Toxicology Letters 207. 2: 137-142.

Ye, X., Wong, L., Bishop, A., Calafat, A. (2011). “Variability of Urinary Concentrations of Bisphenol A in Spot Samples, First Morning Voids, and 24-Hour Collections.Environmental Health Perspectives 119. 7: 983-988.

Zama, A., Uzumcu, M. (2010). “Epigenetic effects of endocrine-disrupting chemicals on female reproduction: An ovarian perspective.” Frontiers in Neuroendocrinology 31. 4: 420-439.

Articles

·       Study: Even BPA-Free Products Leach Endocrine-Disrupting ChemicalsTime, March 2011

·       Beyond BPA: Could 'BPA-Free' Products Be Just as Unsafe? The Atlantic, April 2011

·       Is the Plastic Industry the New Tobacco Industry? The EnvironmentaList, March 2011

·       New research adds to indictments of BPA and pthalates, The Daily Green, January 2009

Books

Baker, N. (2008). The Body Toxic: How the Hazardous Chemistry of Everyday Things Threatens our Health and Well-being. New York, North Point Press.

Grossman, E. (2009). Chasing Molecules: Poisonous products, human health, and the promise of green chemistry. Washington, DC, Island Press/Shearwater Books.

Langston, N. (2010). Toxic bodies: hormone disruptors and the legacy of DES. New Haven, Yale University Press.

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